In 1965, the term "probiotic" was first used to describe "substances secreted by one microorganism that stimulate the growth of another"-in other words, the opposite of an antibiotic.( Schrezenmeir 2001) Revised definitions have appeared in the literature to accommodate mechanisms of action and stimulation of systems other than bacteria. In 1916, experiments were conducted to implant Escherichia coli as a means of fighting pathogenic intestinal flora.( Schrezenmeir 2001) In 76 BC, the Roman historian Plinius described fermented milk as a remedy for gastroenteritis. In a Persian version of the Old Testament, Abraham's longevity was purported to be the result of drinking sour milk. Probiotic preparations have been used throughout history. bacteria should be reconsidered as gut commensals because their prevalence in animal feces is now recognized to be greater than previously thought.( Ghelardi 2015) clausii is one of the most commonly used microorganisms of the Bacillus spp.( Lopetuso 2016) Historically considered to be soil microorganisms, Bacillus spp. have been used for decades in the form of fermentation products or spore-based probiotic supplements however, only a few Bacillus strains are recognized as safe and are available for commercial use.( Ghelardi 2015, Upadrasta 2016) Clinically, B. Related/similar drugs turmeric, Ginkgo Biloba History clausii is a rod-shaped, nonpathogenic, spore-forming, aerobic, gram-positive bacterium that is able to survive transit through the acidic environment of the stomach and colonize the intestine even in the presence of antibiotics.( Ianiro 2018, Urdaci 2004) clausii, Bacillus polyfermentans, and Bacillus cereus. Toxicologyīacillus strains for animal nutritional use and for human use (pharmaceutical preparations) include Bacillus subtilis, Bacillus licheniformis, Bacillus coagulans, Bacillus toyoi (cereus), Bacillus natto (subtilis), B. No adverse effects were noted in clinical trials of B. clausii can be used during pregnancy and lactation and in breastfeeding infants. Pregnancy/LactationĪccording to the product information, B. clausii or to any of the product excipients. Use is recommended for short periods of time. Children and infants: 2 to 4x10 9 spores/day. Manufacturer product information: Adults: 4 to 6x10 9 spores/day (2 to 3 vials/day of suspension or 2 to 3 capsules/day). In clinical studies, typical dosing was 2x10 9 spores administered orally as a capsule or suspension 2 or 3 times daily, for 10 days up to 3 months. pylori eradication (level 1b evidence), but data are insufficient to support probiotic monotherapy as an effective eradication strategy. According to the World Gastroenterology Organization guidelines, data suggest that probiotics as adjuvant therapy may be helpful in H. Small trials have investigated use for prevention of infection in preterm neonates treatment of nasal allergies and upper respiratory infections in children and treatment of acute or chronic diarrhea, small-intestine bacterial overgrowth (SIBO), and adverse effects of Helicobacter pylori therapy in adults. clausii support its use for the treatment and prevention of intestinal bacterial flora disorders, with particular efficacy suggested for diarrhea according to clinical trial data and a systematic review and meta-analysis. The antimicrobial and immunomodulatory properties of B. Common Name(s): Enterogermina, Erceflora, Probiotic
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